I’ve been playing with typing tests for about a year as a way to measure my brain function. I think that typing is a unique test because it uses parts of the brain that I consider important. The hipppocampus and cerebellum.
The cerebellum is known for it’s involvement in motor control and the hippocampus in short and long term memory and spacial awareness. The deterioration of these areas of the brain also happen to be involved in things like dementia and thyroid malfunction.
Some things I’ve noticed. Butter, chocolate, cigarettes, thyroid hormone (or thyroid supporting substances), and fatty cuts of pork (probably the glycine, although I haven’t tested with gelatin) tends to improve both my speed and accuracy. Significantly.
It seems that all these substances seem to have immediate boosting effects. Pork fat seems to have a longer lasting effect in that you don’t seem to need to eat it every day to maintain a result. Pork seems to outperform butter in the lasting effect, and chocolate seems to be like octane. Stearic acid has many neuroprotective effects which high fat chocolate is rich in. Butter seems to have more a calming effect (reduced stress?) which allows better brain function.
Cigarettes seem to work best on a high fat diet where complex I is fairly inactive anyway.
My guess besides having favorable affects on mitochondria is that all these substances (aside from the pork) also seem to modulate LPS (endotoxin) in appropriate ways. That does not necessarily mean decreasing or lowering LPS but rather modulating it in favorable ways. LPS seems to be more complicated than a more or less scenario.
There is some room in here for tight junctions and calcium channeling but other things to do at the moment.
Cormier, A., Morin, C., Zini, R., Tillement, J.-P., & Lagrue, G. (2001). In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation. Brain Research, 900(1), 72–79. Retrieved from http://www.sciencedirect.com/science/article/pii/S0006899301022545
Gray, R., Rajan, A., Radcliffe, K., Yakehiro, M., & Dani, J. (1996). Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature. Retrieved from http://neuro.bcm.edu/_web/danilab/files/383713a0.pdf
Hogan, M. J., Staff, R. T., Bunting, B. P., Murray, A. D., Ahearn, T. S., Deary, I. J., & Whalley, L. J. (2011). Cerebellar brain volume accounts for variance in cognitive performance in older adults. Cortex; a journal devoted to the study of the nervous system and behavior, 47(4), 441–50. doi:10.1016/j.cortex.2010.01.001
Wang, J., Kim, J.-M., Donovan, D. M., Becker, K. G., & Li, M. D. (2009). Significant modulation of mitochondrial electron transport system by nicotine in various rat brain regions. Mitochondrion, 9(3), 186–95. doi:10.1016/j.mito.2009.01.008
Wang, Z.-J., Liang, C.-L., Li, G.-M., Yu, C.-Y., & Yin, M. (2007). Stearic acid protects primary cultured cortical neurons against oxidative stress. Acta pharmacologica Sinica, 28(3), 315–26. doi:10.1111/j.1745-7254.2007.00512.x