Internet

Regular Internet at the house will be up on the 16th of December. Looking forward to some regular writing. I’m not sure exactly what I want to do with this, but I have read that some people enjoy what I write, I do enjoy writing and do enjoy doing the research (exploring) for what I write probably more so than the writing. There is a overall theme to what I write but if there is something you’d like me to write about or look into, I can’t promise anything but I would be willing to write on subjects that you who read this are interested in reading about.

Governing dynamics

Not much anymore do I entertain the idea that there is template diet for people to eat and be healthy on (cough… butter). In the end what is a good diet usually follows some sort of common sense. Of course common sense is a hard commodity to come by for most that have grown up in Western culture where food is abundant and survival that counts on one finding food is obsolete.

More so, I find that people who are interested in “nutrition” are unfortunately some of the sickest people I have come to know in my life, not only do they suffer from day-to-day with choosing foods to eat, but they also suffer with varying degrees of the opposite of cognitive clarity. As Peter writes in so many words there are in fact very few normal people…

Of course this is not some semantic logic designed to say that common sense would be this or that, and if you don’t agree with my common sense then you lack common sense, but rather, common sense is: the ability to think and reason on your own.

There are an abundance of brilliant and free-thinking people in the world. And for every one of those people there are a google of people claiming that the brilliant person they defend (for whatever reason) is correct, not just correct in one or two things but most things; most of the time I find this defense to be for self-confirmation rather than anything remotely resembling something of noble virtue.

People have this idea that if someone is correct about one thing and that one thing happens to impact their life for the better, then the brilliant person who discovered a morsel of applicable truth, must by extension then be correct about other things. Perhaps.

Perhaps not. And it is the perhaps not that people seem to have trouble with, and I postulate that this problem stems from the concept of sin and perfection from Christendom. People have a really hard time accepting that brilliance comes in short stories not novels. If a man is right about one thing, and wrong about another thing, then that right thing will be questioned. People seem to have a hard time excepting the paradox that reason can give you a truth but that same reason (framework) can lead to very wrong conclusions.

Where you find a brilliant person with a brilliant idea, you will find googles of people in some form or another twisting that brilliant idea, into a dogma. I always found that rude. But while rude, this is what Max Weber the sociologist observed when dogmas create dilemmas. Worse, those people defend the progenitor of the idea as if they are soldiers of some noble cause, some personal friend. I’ve always found that rude as well and more than slightly ignorant.

Perhaps it is time that we allow governing dynamics a chance to take over. Nash and Smith both understood this concept, one mathematically minded and the latter economically minded.

Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens

Mishra, N. C., Rir-Sima-Ah, J., Langley, R. J., Singh, S. P., Peña-Philippides, J. C., Koga, T., … Sopori, M. L. (2008). Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. Journal of immunology (Baltimore, Md. : 1950), 180(11), 7655–63. Retrieved from http://www.jimmunol.org/content/180/11/7655.full

Allergic asthma, an inflammatory disease characterized by the infiltration and activation of various leukocytes, the production of Th2 cytokines and leukotrienes, and atopy, also affects the function of other cell types, causing goblet cell hyperplasia/hypertrophy, increased mucus production/secretion, and airway hyperreactivity. Eosinophilic inflammation is a characteristic feature of human asthma, and recent evidence suggests that eosinophils also play a critical role in T cell trafficking in animal models of asthma. Nicotine is an anti-inflammatory, but the association between smoking and asthma is highly contentious and some report that smoking cessation increases the risk of asthma in ex-smokers. To ascertain the effects of nicotine on allergy/asthma, Brown Norway rats were treated with nicotine and sensitized and challenged with allergens. The results unequivocally show that, even after multiple allergen sensitizations, nicotine dramatically suppresses inflammatory/allergic parameters in the lung including the following: eosinophilic/lymphocytic emigration; mRNA and/or protein expression of the Th2 cytokines/chemokines IL-4, IL-5, IL-13, IL-25, and eotaxin; leukotriene C(4); and total as well as allergen-specific IgE. Although nicotine did not significantly affect hexosaminidase release, IgG, or methacholine-induced airway resistance, it significantly decreased mucus content in bronchoalveolar lavage; interestingly, however, despite the strong suppression of IL-4/IL-13, nicotine significantly increased the intraepithelial-stored mucosubstances and Muc5ac mRNA expression. These results suggest that nicotine modulates allergy/asthma primarily by suppressing eosinophil trafficking and suppressing Th2 cytokine/chemokine responses without reducing goblet cell metaplasia or mucous production and may explain the lower risk of allergic diseases in smokers. To our knowledge this is the first direct evidence that nicotine modulates allergic responses.

Experiences at altitude: part 1

These initial posts will serve as observations and note my experiences, speculation and explanatory ideas will come later. I will write what I can when I can as I’m without regular Internet access still.

Earlier this year I went to Santa Fe, New Mexico for a little over 3 months. Santa Fe is close to 7000 feet above sea level and the climate is dry. The evenings can be cool when there is no cloud cover and the days during the summer time can be miserably hot; it is quite easy to sunburn.

As someone who is hyperaware enough to feel my own cells turnover I was interested in the effects that might occur as I settled in my new environment.

When I was a child I suffered with severe asthma, one of things I learned to do when I had trouble breathing was to pull the covers over my head and breathe the warm air. That always seemed to help. Sometimes I would wake up in the morning completely under the covers as if I had been under there all night. I don’t know if I was under there all night, but obviously I was pulling them over my head in my sleep as well. I was a brother of the naked mole rat. (Except that butter has a profoundly powerful effect at relaxing the lungs, lowers lipid peroxidation of the PUFA sort and eosinophil counts… better then living underground.)

I have not had asthma symptoms for a long time, not being able to breathe especially as a child puts an interesting perspective on the rest of your life and you realize very quickly what gases are important.

Prior to my arrival in Santa Fe the only times I’ve had trouble with breathing since childhood was during the period I was experimenting with Aspirin and when I transitioned from a carbohydrate restricted diet to a unrestricted one. That transition had me in the hospital hooked up to a breathing machine with only the best steroids.

When I arrived at altitude I was not sure what to expect nor had expectations but when I got off the plane the air was clear and crisp and I didn’t find it difficult to breathe or anything of that nature. For the first couple weeks if I was doing something harder than walking I would pant but when I would squat for singles or doubles I would not have the panting. Mostly because singles and doubles avoid the glycolytic metabolic pathways. I did not have regular gym access for a while so initially I was sedentary.

I had an irregular sleep schedule from the time change (Germany). I’ve never had what you’d consider a normal sleep schedule. I’ve always been somewhat of a night owl, o.k. more than just a night owl, more like a burning the midnight oil till morning person and sleep when I’m tired.

I’ve never been a person to believe in theoretical nutrition and I view sleep much the same way. I sleep when I’m tired and am awake when I’m not. I never really viewed a certain sleep time as healthful or unhealthful—just that poor sleep quality is a marker for poor health—in other words when tired if you sleep and wake up rested that is good, and if you are tired and can’t sleep and don’t feel rested then that is not good. The sleeping patterns of traditionals were quite irregular and they were seemingly healthy so I never gave that theory, the theory of some sleep at some specific time of the day any credibility.

Anyhow the latter is what happened at altitude. The bad sleep. I could not sleep normally, and additionally I would have trouble breathing when I would try to sleep. That went on the entire time I was there. There wasn’t a single thing I tried that worked for more than a day or two. And when I would try something that seemed to work it would its effectiveness like clockwork about 2 days later.

After about 2 or 3 weeks I begin to have joint pain, my knees especially started to sound like there was sand inside of them every time I would bend at the knees. This continued on till I left and the only thing that seemed to help was dairy, butter seemed to be the most effective. Indeed most high altitude cultures are dairy based.

O.k. a page or so for now, will continue on later.

Oh, almost forgot my typing tests declined as well.

This post will be updated with references as soon as I have regular access to databases again.

Experiences at altitude

I’ve just come back down from altitude after being at roughly 2100m for close to 3 months. I want to expand on this experience a lot actually as there were a lot of things that I noticed while at altitude. I don’t have time at the moment to write as I am in between countries but this is the biggest topic on my mind at the moment. Once I get settled (and a regular Internet connection) this blog will be more regular. Cheers.