Triiodothyronine-mediated up-regulation of UCP2 and UCP3 mRNA expression in human skeletal muscle without coordinated induction of mitochondrial respiratory chain genes

Triiodothyronine (T3) increases mitochondrial respiration and promotes, in rodents, the uncoupling between oxygen consumption and ATP synthesis. The T3 effect is mediated partly through transcriptional control of genes encoding mitochondrial proteins. Here, we determined the effect of T3 on mRNA levels of uncoupling proteins (UCP) and proteins involved in the biogenesis of the respiratory chain in human skeletal muscle and on UCP2 mRNA expression in adipose tissue.

“T3 is also known to stimulate fatty acid oxidation. The decrease in respiratory quotient observed in our study suggests that T3 treatment induced an increase in fatty acid oxidation.”

Low-dose radiation, n-butyrate, and fatty acid composition on the action of thyroid hormones

Just moved to New York. Getting settled in etc., once things are settled will resume writing. For the time being came across some things I found worth reading.

This one is a post on low-dose radiation coming from Stan’s blog.

The rest are interesting papers:

Galo, M. G., Uñates, L. E., & Farías, R. N. (1981). Effect of membrane fatty acid composition on the action of thyroid hormones on (Ca2+ + Mg2+)-adenosine triphosphatase from rat erythrocyte. The Journal of biological chemistry, 256(14), 7113–4. Retrieved from

The action of L-triiodothyronine, L-thyroxine, and their analogues on the (Ca2+ + Mg2+)-ATPase of erythrocytes from rats fed with two different fat-supplemented diets has been studied. It was found that only L-triiodothyronine and L-thyroxine have effects on the (Ca2+ + Mg2+)-ATPase of both groups, producing inhibition in rats fed with corn oil and activation in rats fed with lard-supplemented diets. The half-maximal effect for L-triiodothyronine and L-thyroxine are, respectively, on the order of 10(-10) and 10(-8) M. These changes were not obtained with analogues of the hormones. It is suggested that the response of this enzymatic system to the hormonal action is conditioned by the fatty acid composition of membrane-bound lipids. This observation is novel in the hormonal research area.

Ortiz-Caro, J., Montiel, F., Pascual, A., & Aranda, A. (1986). Modulation of thyroid hormone nuclear receptors by short-chain fatty acids in glial C6 cells. Role of histone acetylation. J. Biol. Chem., 261(30), 13997–14004. Retrieved from

Mitsuhashi, T., Uchimura, H., & Takaku, F. (1987). n-Butyrate increases the level of thyroid hormone nuclear receptor in non-pituitary cultured cells. J. Biol. Chem., 262(9), 3993–3999. Retrieved from