Hormetic Endocrinology

Mon, 20 Apr 2026 00:00:00 +0000

Orthodox endocrinology treats hormone replacement as a problem of restoration: levels are low, so we raise them; the target is a steady state within reference ranges. This framing has served medicine well for hypothyroidism and hypogonadism alike. But it leaves unexplored a different question—whether strategic, cyclical perturbation of hormonal systems might produce adaptations that static replacement cannot. What I want to do here is construct a theoretical framework for that question, grounded in what the literature actually supports, honest about where speculation begins, and structured enough to generate falsifiable predictions.

Hormesis on Edward J. Edmonds

Hormetic Endocrinology